Trifluoromethylthiobenzene Property

Boiling point:

142 °C (lit.)

Density 

1.249 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.466(lit.)

Flash point:

100 °F

form 

clear liquid

color 

Colorless to Almost colorless

Sensitive 

Stench

BRN 

2043134

CAS DataBase Reference

456-56-4(CAS DataBase Reference)

NIST Chemistry Reference

Phenyl trifluoromethyl sulfide(456-56-4)

Safety

Hazard Codes 

T

Risk Statements 

10-36/37/38

Safety Statements 

16-36-36/37/39-23

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Toxic/Stench

HazardClass 

3

PackingGroup 

III

HS Code 

29309090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Trifluoromethylthiobenzene Chemical Properties,Usage,Production

Uses

Phenyl trifluoromethyl sulfide may be used in the preparation of:

• sulfoxides, dithiane dioxide, and dithiolane dioxide via iron-catalyzed oxidation of sulfides, dithiane, or dithiolane with hydrogen peroxide
• benzophenone hydrazone derivatives
• trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 4047, 1985 DOI: 10.1021/jo00221a017
Synthesis, p. 721, 1975 DOI: 10.1055/s-1975-23905

General Description

Phenyl trifluoromethyl sulfide (PTFMS) is an aryl trifluoromethyl sulfide. PTFMS with (triethylgermyl)sodium forms a reagent system that has been employed for the trifluoromethylation of certain imines. The reaction between OH radical and PTFMS has been analyzed using pulse radiolysis technique and quantum chemical calculations.